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1

Enhanced expression of transforming growth factor-β and its type-I and type-II receptors in human glioblastoma

Naoshi Yamada, Mitsuyasu Kato, Hidetoshi Yamashita, Monica Nistér, Kohei Miyazono, Carl-Henrik Heldin, Keiko Funa

Journal:

International Journal of Cancer

Year:

1995

Language:

english

File:

PDF, 889 KB

english, 1995

2

Mechanisms of TGF-β signaling in regulation of cell growth and differentiation

Aristidis Moustakas, Katerina Pardali, Annamaria Gaal, Carl-Henrik Heldin

Journal:

Immunology Letters

Year:

2002

Language:

english

File:

PDF, 298 KB

english, 2002

3

Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor

Ek, Bo, Westermark, Bengt, Wasteson, Åke, Heldin, Carl-Henrik

Journal:

Year:

1982

File:

PDF, 305 KB

1982

4

Role for carbohydrate structures inTGF-β1 latency

Miyazono, Kohel, Heldin, Carl-Henrik

Journal:

Year:

1989

File:

PDF, 351 KB

1989

5

High interstitial fluid pressure — an obstacle in cancer therapy

Heldin, Carl-Henrik, Rubin, Kristofer, Pietras, Kristian, Östman, Arne

Journal:

Nature Reviews Cancer

Year:

2004

Language:

english

File:

PDF, 227 KB

english, 2004

6

PDGF receptors as cancer drug targets

Kristian Pietras, Tobias Sjöblom, Kristofer Rubin, Carl-Henrik Heldin, Arne Östman

Journal:

Year:

2003

Language:

english

File:

PDF, 281 KB

english, 2003

7

Coexpression of the sis and myc proto-oncogenes in developing human placenta suggests autocrine control of trophoblast growth

Goustin, Anton Scott, Betsholtz, Christer, Pfeifer-Ohlsson, Susan, Persson, Håkan, Rydnert, Jan, Bywater, Margaret, Holmgren, Gösta, Heldin, Carl-Henrik, Westermark, Bengt, Ohlsson, Rolf

Journal:

Year:

1985

Language:

english

File:

PDF, 25.34 MB

english, 1985

8

Growth Factors and Oncogenes in Human Malignant Glioma

Westermark, Bengt, Nister, Monica, Heldin, Carl-Henrik

Journal:

Neurologic Clinics

Year:

1985

Language:

english

File:

PDF, 2.75 MB

english, 1985

9

Expression of transforming-growth-factor (TGF)-β receptors and Smad proteins in glioblastoma cell lines with distinct responses to TGF-β1

Ester Piek, Ulrica Westermark, Marianne Kastemar, Carl-Henrik Heldin, E. Joop van Zoelen, Monica Nistér, Peter Ten Dijke

Journal:

International Journal of Cancer

Year:

1999

Language:

english

File:

PDF, 268 KB

english, 1999

10

Expression of Smad proteins in human colorectal cancer

Olexander Korchynskyi, Maréne Landström, Rostyslav Stoika, Keiko Funa, Carl-Henrik Heldin, Peter ten Dijke, Serhiy Souchelnytskyi

Journal:

International Journal of Cancer

Year:

1999

Language:

english

File:

PDF, 646 KB

english, 1999

11

Characterization of a 60-kDa cell surface-associated transforming growth factor-β binding protein that can interfere with transforming growth factor-β receptor binding

Ester Piek, Petra Franzèn, Carl-Henrik Heldin, Peter Ten Dijke

Journal:

Journal of Cellular Physiology

Year:

1997

Language:

english

File:

PDF, 419 KB

english, 1997

12

Intracellular signaling of osteogenic protein-1 through Smad5 activation

Kiyoshi Tamaki, Serhiy Souchelnytskyi, Susumu Itoh, Atsuhito Nakao, Kuber Sampath, Carl-Henrik Heldin, Peter Ten Dijke

Journal:

Journal of Cellular Physiology

Year:

1998

Language:

english

File:

PDF, 343 KB

english, 1998

13

Functional antagonism between activin and osteogenic protein-1 in human embryonal carcinoma cells

Ester Piek, Mozhgan Afrakhte, Kuber Sampath, E. Joop Van Zoelen, Carl-Henrik Heldin, Peter Ten Dijke

Journal:

Journal of Cellular Physiology

Year:

1999

Language:

english

File:

PDF, 237 KB

english, 1999

14

Mechanisms of platelet-derived growth factor–induced chemotaxis

Lars Rönnstrand, Carl-Henrik Heldin

Journal:

International Journal of Cancer

Year:

2001

Language:

english

File:

PDF, 89 KB

english, 2001

15

Platelet-derived growth factor in human glioma

Bengt Westermark, Carl-Henrik Heldin, Monica Nistér

Journal:

Year:

1995

Language:

english

File:

PDF, 909 KB

english, 1995

16

Identification of a subset of pericytes that respond to combination therapy targeting PDGF and VEGF signaling

Yoko Hasumi, Agnieszka Kłosowska-Wardęga, Masao Furuhashi, Arne Östman, Carl-Henrik Heldin, Carina Hellberg

Journal:

International Journal of Cancer

Year:

2007

Language:

english

File:

PDF, 391 KB

english, 2007

17

Filamin a mediates HGF/c-MET signaling in tumor cell migration

Alex-Xianghua Zhou, Aslı Toylu, Rajesh K. Nallapalli, Gisela Nilsson, Neşe Atabey, Carl-Henrik Heldin, Jan Borén, Martin O. Bergo, Levent M. Akyürek

Journal:

International Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 1.45 MB

english, 2011

18

Expression of multiple growth factors in a human lung cancer cell line

Christer Betsholtz, Jonas Bergh, Margaret Bywater, Monica Pettersson, Ann Johnsson, Carl-Henrik Heldin, Rolf Ohlsson, Timothy J. Knott, James Scott, Graeme I. Bell, Bengt Westermark

Journal:

International Journal of Cancer

Year:

1987

Language:

english

File:

PDF, 1.11 MB

english, 1987

19

Platelet-derived endothelial cell growth factor

Carl-Henrik Heldin, Kensuke Usuki, Kohei Miyazono

Journal:

Journal of Cellular Biochemistry

Year:

1991

Language:

english

File:

PDF, 247 KB

english, 1991

20

Chemical and biological properties of a growth factor from human-cultured osteosarcoma cells: Resemblance with platelet-derived growth factor

Carl-Henrik Heldin, Bengt Westermark, Åke Wasteson

Journal:

Journal of Cellular Physiology

Year:

1980

Language:

english

File:

PDF, 843 KB

english, 1980

21

Similar action of platelet-derived growth factor and epidermal growth factor in the prereplicative phase of human fibroblasts suggests a common intracellular pathway

Bengt Westermark, Carl-Henrik Heldin

Journal:

Journal of Cellular Physiology

Year:

1985

Language:

english

File:

PDF, 679 KB

english, 1985

22

PDGF-like growth factors in autocrine stimulation of growth

Carl-Henrik Heldin, Bengt Westermark

Journal:

Journal of Cellular Physiology

Year:

1987

Language:

english

File:

PDF, 389 KB

english, 1987

23

Induction of cyclic AMP synthesis by forskolin is followed by a reduction in the expression of c-myc messenger RNA and inhibition of 3H-thymidine incorporation in human fibroblasts

Nils-Erik Heldin, Ylva Paulsson, Karin Forsberg, Carl-Henrik Heldin, Bengt Westermark

Journal:

Journal of Cellular Physiology

Year:

1989

Language:

english

File:

PDF, 785 KB

english, 1989

24

Pool of ligand-bound platelet-derived growth factor β-receptors remain activated and tyrosine phosphorylated after internalization

Alexander Sorkin, Anders Eriksson, Carl-Henrik Heldin, Bengt Westermark, Lena Claesson-Welsh

Journal:

Journal of Cellular Physiology

Year:

1993

Language:

english

File:

PDF, 1.14 MB

english, 1993

25

Activated platelet-derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line

Flemming S. Vassbotn, Arne Östman, Nina Langeland, Holm Holmsen, Bengt Westermark, Carl-Henrik Heldin, Monica Nistér

Journal:

Journal of Cellular Physiology

Year:

1994

Language:

english

File:

PDF, 1.03 MB

english, 1994

26

Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21WAF1/Cip1

Katerina Pardali, Marcin Kowanetz, Carl-Henrik Heldin, Aristidis Moustakas

Journal:

Journal of Cellular Physiology

Year:

2005

Language:

english

File:

PDF, 724 KB

english, 2005

27

Effect of epidermal growth factor on membrane motility and cell locomotion in cultures of human clonal glioma cells

Bengt Westermark, Annika Magnusson, Carl-Henrik Heldin

Journal:

Journal of Neuroscience Research

Year:

1982

Language:

english

File:

PDF, 1.16 MB

english, 1982

28

Effect of transforming growth factor-β and platelet-derived growth factor-BB on articular cartilage in rats

Anders Hulth, Olof Johnell, Kohei Miyazono, Lisbeth Lindberg, Dick Heinegård, Carl-Henrik Heldin

Journal:

Journal of Orthopaedic Research

Year:

1996

Language:

english

File:

PDF, 884 KB

english, 1996

29

Identification of receptors and Smad proteins involved in activin signalling in a human epidermal keratinocyte cell line

Akira Shimizu, Mitsuyasu Kato, Atsuhito Nakao, Takeshi Imamura, Peter Ten Dijke, Carl-Henrik Heldin, Masahiro Kawabata, Shinji Shimada, Kohei Miyazono

Journal:

Year:

1998

Language:

english

File:

PDF, 621 KB

english, 1998

30

Smad7 and protein phosphatase 1α are critical determinants in the duration of TGF-β/ALK1 signaling in endothelial cells

Gudrun Valdimarsdottir, Marie-José Goumans, Fumiko Itoh, Susumu Itoh, Carl-Henrik Heldin, Peter ten Dijke

Journal:

BMC Cell Biology

Year:

2006

Language:

english

File:

PDF, 664 KB

english, 2006

31

2R and remodeling of vertebrate signal transduction engine

Lukasz Huminiecki, Carl Henrik Heldin

Journal:

Year:

2010

Language:

english

File:

PDF, 492 KB

english, 2010

32

The effect of platelet-derived growth factor on morphology and motility of human glial cells

Karin Mellström, Anna-Stina Höglund, Monica Nistér, Carl-Henrik Heldin, Bengt Westermark, Uno Lindberg

Journal:

Journal of Muscle Research and Cell Motility

Year:

1983

Language:

english

File:

PDF, 5.99 MB

english, 1983

33

The mechanism of action of transforming growth factor-β

Kohei Miyazono, Carl-Henrik Heldin

Journal:

Journal of Gastroenterology

Year:

1993

Language:

english

File:

PDF, 578 KB

english, 1993

34

Structural and functional aspects of platelet-derived growth factor and its role in the pathogenesis of glioblastoma

Christer Betsholtz, Monica Nistér, Fredrik Rorsman, Carl-Henrik Heldin, Bengt Westermark

Journal:

Molecular and Chemical Neuropathology (Neurochemical Pathology)

Year:

1989

Language:

english

File:

PDF, 700 KB

english, 1989

35

Role of Smads in TGFβ signaling

Carl-Henrik Heldin, Aristidis Moustakas

Journal:

Cell and Tissue Research

Year:

2012

Language:

english

File:

PDF, 423 KB

english, 2012

36

Signaling networks guiding epithelial–mesenchymal transitions during embryogenesis and cancer progression

Aristidis Moustakas, Carl-Henrik Heldin

Journal:

Year:

2007

Language:

english

File:

PDF, 303 KB

english, 2007

37

10.1038/16357

Dijke, Peter ten, Heldin, Carl-Henrik

Journal:

Year:

1999

Language:

english

File:

PDF, 213 KB

english, 1999

38

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus

Waterfield, Michael D., Scrace, Geoffrey T., Whittle, Nigel, Stroobant, Paul, Johnsson, Ann, Wasteson, Åke, Westermark, Bengt, Heldin, Carl-Henrik, Huang, Jung San, Deuel, Thomas F.

Journal:

Year:

1983

File:

PDF, 732 KB

1983

39

Antibodies against platelet-derived growth factor inhibit acute transformation by simian sarcoma virus

Johnsson, Ann, Betsholtz, Christer, Heldin, Carl-Henrik, Westermark, Bengt

Journal:

Year:

1985

File:

PDF, 624 KB

1985

40

A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains

Heldin, Carl-Henrik, Johnsson, Ann, Wennergren, Suzanne, Wernstedt, Christer, Betsholtz, Christer, Westermark, Bengt

Journal:

Year:

1986

File:

PDF, 506 KB

1986

41

cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

Betsholtz, Christer, Johnsson, Ann, Heldin, Carl-Henrik, Westermark, Bengt, Lind, Peter, Urdea, Mickey S., Eddy, Roger, Shows, Thomas B., Philpott, Karen, Mellor, Andrew L.

Journal:

Year:

1986

File:

PDF, 559 KB

1986

42

Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor

Ishikawa, Fuyuki, Miyazono, Kohei, Hellman, Ulf, Drexler, Hannes, Wernstedt, Christer, Hagiwara, Koichi, Usuki, Kensuke, Takaku, Fumimaro, Risau, Werner, Heldin, Carl-Henrik

Journal:

Year:

1989

File:

PDF, 776 KB

1989

43

10.1038/35074588

Bergsten, Erika, Uutela, Marko, Li, Xuri, Pietras, Kristian, Östman, Arne, Heldin, Carl-Henrik, Alitalo, Kari, Eriksson, Ulf

Journal:

Nature Cell Biology

Year:

2001

Language:

english

File:

PDF, 469 KB

english, 2001

44

10.1038/37284

Heldin, Carl-Henrik, Miyazono, Kohei, ten Dijke, Peter

Journal:

Year:

1997

Language:

english

File:

PDF, 308 KB

english, 1997

45

10.1038/39369

Dijke, Peter ten, Nakao, Atsuhito, Afrakhte, Mozhgan, Morn, Anita, Nakayama, Takuya, Christian, Jan L., Heuchel, Rainer, Itoh, Susumu, Kawabata, Masahiro, Heldin, Nils-Erik, Heldin, Carl-Henrik

Journal:

Year:

1997

Language:

english

File:

PDF, 506 KB

english, 1997

46

10.1038/70223

Heldin, Carl-Henrik, ten Dijke, Peter

Journal:

Nature Cell Biology

Year:

1999

Language:

english

File:

PDF, 126 KB

english, 1999

47

Feedback Control: The role of negative feedback in signal transduction control

Heldin, Carl-Henrik, Lennartsson, Johan, Hellberg, Carina

Journal:

European Journal of Human Genetics

Year:

2008

Language:

english

File:

PDF, 64 KB

english, 2008

48

Platelet-derived growth factor: Isoform-specific signalling via heterodimeric or homodimeric receptor complexes

Heldin, Carl-Henrik, Östman, Arne, Eriksson, Anders, Siegbahn, Agneta, Claesson-Welsh, Lena, Westermark, Bengt

Journal:

Kidney International

Year:

1992

Language:

english

File:

PDF, 472 KB

english, 1992

49

A gain-of-function mutation in the PDGFR-β alters the kinetics of injury response in liver and skin

Heldin, Carl-Henrik, Heuchel, Rainer L, Krampert, Monika

Journal:

Laboratory Investigation

Year:

2008

Language:

english

File:

PDF, 776 KB

english, 2008

50

The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

Heldin, Carl-Henrik, Landström, Maréne, Sorrentino, Alessandro, Thakur, Noopur, Grimsby, Susanne, Marcusson, Anders, von Bulow, Verena, Schuster, Norbert, Zhang, Shouting

Journal:

Nature Cell Biology

Year:

2008

Language:

english

File:

PDF, 2.23 MB

english, 2008

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